Publications

Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2

Salihovic Admir, Ascham Alex, Rosenqvist Petja S, Taladriz-Sender Andrea, Hoskisson Paul A, Hodgson David R W, Grogan Gideon, Burley Glenn A

Chemical Science Vol 16, pp. 1302-1307 (2024)

https://doi.org/10.1039/D4SC07521H

Reactivity profiling for high yielding Ynamine-tagged oligonucleotide click chemistry bioconjugations

Peschke Frederik, Taladriz-Sender Andrea, Watson Allan JB, Burley Glenn A

Bioconjugate Chemistry Vol 35, pp. 1788-1796 (2024)

https://doi.org/10.1021/acs.bioconjchem.4c00353

Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2

Salihovic Admir, Ascham Alex, Taladriz-Sender Andrea, Bryson Samantha, Withers Jamie M, Mckean Iain J W, Hoskisson Paul A, Grogan Gideon, Burley Glenn A

Chemical Science Vol 15, pp. 15399-15407 (2024)

https://doi.org/10.1039/D4SC04938A

Mechanistic basis of the Cu(OAc)2 catalyzed azide-ynamine (3+2)cycloaddition reaction

Bunschoten Roderick P, Peschke Frederik, Taladriz-Sender Andrea, Alexander Emma, Andrews Matthew J, Kennedy Alan R, Fazakerley Neal J, Lloyd Jones Guy C, Watson Allan J B, Burley Glenn A

Journal of the American Chemical Society Vol 146, pp. 13558-13570 (2024)

https://doi.org/10.1021/jacs.4c03348

2′-¹⁹ F labelling of ribose in RNAs : a tool to analyse RNA/protein interactions by NMR in physiological conditions

Kara Hesna, Axer Alexander, Muskett Frederick W, Bueno-Alejo Carlos J, Paschalis Vasileios, Taladriz-Sender Andrea, Tubasum Sumera, Vega Marina Santana, Zhao Zhengyun, Clark Alasdair W, Hudson Andrew J, Eperon Ian C, Burley Glenn A, Dominguez Cyril

Frontiers in Molecular Biosciences Vol 11 (2024)

https://doi.org/10.3389/fmolb.2024.1325041

Glutathione mediates control of dual differential bio-orthogonal labelling of biomolecules

Peschke Frederik, Taladriz-Sender Andrea, Andrews Matthew J, Watson Allan J B, Burley Glenn A

Angewandte Chemie International Edition Vol 62 (2023)

https://doi.org/10.1002/anie.202313063

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Professional Activities

Facility Showcase Event

Participant

20/5/2025

In Cell NMR – Developing Cellular Characterization Tools for Oligonucleotide Therapeutics

Speaker

17/5/2023

Establishing a chemical biological toolbox to understand the mechanisms of splice-switching small molecules

Speaker

29/1/2022

Chemical Biological Strategies to Modulate Gene Expression

Speaker

15/9/2021

Development of Splice-Switching Molecules as Inducers of Apoptosis

Speaker

24/6/2019

Nucleic acid assembly mediated by the fluorous effect

Speaker

6/7/2018

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Projects

GLAS-CYTO: AN INTEGRATED FACILITY FOR THE BIOPHYSICAL ANALYSIS OF CELLULAR INTERACTIONS

Burley, Glenn (Principal Investigator) Chamberlain, Luke (Co-investigator) Chow, Shiao (Co-investigator) Corrigan, Damion (Co-investigator) Cunningham, Margaret Rose (Co-investigator) Faulds, Karen (Co-investigator) Jamieson, Craig (Co-investigator) Rattray, Zahra (Co-investigator) Tomkinson, Nick (Co-investigator) Taladriz Sender, Andrea (Research Co-investigator)

01-Jan-2024 - 31-Jan-2025

NMR-BASE: Nuclear Magnetic Resonance for Biomolecule Analysis in Supported Environments

Parkinson, John (Principal Investigator) Burley, Glenn (Co-investigator) Dufès, Christine (Co-investigator) Irving, Craig (Co-investigator) Jamieson, Craig (Co-investigator) Scott, Fraser (Co-investigator) Seib, Philipp (Co-investigator) Taladriz Sender, Andrea (Co-investigator)

01-Jan-2023 - 31-Jan-2024

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